Concepedia

Mendelian Randomization Study of <i>ACLY</i> and Cardiovascular Disease

Brian A. Ference, Kausik K. Ray, Alberico L. Catapano, Thatcher B. Ference, Stephen Burgess, David Neff, Clare Oliver‐Williams, Angela Wood, Adam S. Butterworth, Emanuele Di Angelantonio,

New England Journal of Medicine · 2019 · 327 citations · 18 references

DOIFull text

Open access

Abstract

Genetic variants that mimic the effect of ATP citrate lyase inhibitors and statins appeared to lower plasma LDL cholesterol levels by the same mechanism of action and were associated with similar effects on the risk of cardiovascular disease per unit decrease in the LDL cholesterol level. (Funded by Esperion Therapeutics and others.).

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