Reproducibility and non-redundancy of radiomic features extracted from arterial phase CT scans in hepatocellular carcinoma patients: impact of tumor segmentation variability

Abstract

Our study demonstrates that variations exist in the reproducibility of quantitative imaging features extracted from tumor regions segmented using different methods. The reproducibility and non-redundancy of the radiomic features rely greatly on the tumor segmentation in HCC CT images. We recommend that the most reliable and uniform radiomic features should be selected in the clinical use of radiomics. Classification experiments with feature reduction showed that radiomic features were effective in identifying healthy liver and HCC.