SOCS3 ablation enhances DC-derived Th17 immune response against Candida albicans by activating IL-6/STAT3 in vitro

Abstract

As with SOCS1 in our previous report, suppression of SOCS3 alone also has the potential to fully activate DCs maturation. However, while SOCS1 knockdown in DCs during C. albicans infection specifically augments Th1 differentiation, SOCS3 silencing particularly increases Th17 differentiation.