Synthesis of Tridentate Chiral Spiro Aminophosphine−Oxazoline Ligands and Application to Asymmetric Hydrogenation of α‐Keto Amides

Abstract

Abstract A new type of tridentate chiral spiro aminophosphine−oxazoline ligands (SpiroOAP) have been synthesized through four steps. The SpiroOAP ligands are highly efficient for the asymmetric hydrogenation of α‐keto amides, providing a variety of synthetically useful α‐hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000). magnified image