Journal of Cancer Research and Therapeutics · 2018 · 18 citations · 9 references
MedicineOncologyPharmacologyApoptosisChemotherapyMolecular OncologyCombination Cancer TherapyCombination ChemotherapyCytotoxic ChemotherapyMalignant NeoplasmsPancreatic CancerRadiation TherapyCancer Cell Proliferation InhibitionCell Cycle Arrest MechanismsCellular ProliferationChemotherapy-induced ApoptosisClonogenic PotentialGemcitabine-based TherapyMetastatic Pancreatic CancerRadiation-induced Apoptosis
BACKGROUND: I and GEM on pancreatic carcinoma cells (PANC-1) cells and explore the underlying molecular basis. SUBJECTS AND METHODS: I continuously at a low dose of radiation, combined with or without sensitizing concentration of GEM. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, and molecular pathways of the cells following these treatments were analyzed in vitro. RESULTS: I or GEM alone. CONCLUSION: I and GEM-induced stronger anti-proliferation effect than single-treatment, due to the cell cycle arrest and more cellular apoptosis in PANC-1 cells. The increased Bax/Bcl-2 ratio may lead to enhanced apoptosis.
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