Efficacy of Mindfulness-based Stress Reduction in Hemodialysis Patients with Anxiety and Depression: a randomized, double-blind, parallel-group trial

Abstract

Background: Diseases with a chronic and debilitating nature, such as chronic kidney disease, are frequently associated with psychiatric disorders like anxiety and depression. Objective: To assess the efficacy of mindfulness-based stress reduction (MBSR) on anxiety and depression in hemodialysis patients. Methods: In this randomized clinical trial, fifty hemodialysis patients were selected from two dialysis centers of Kashan city in Iran in 2016. The patients had desired cognitive status based on MMSE (Mini Mental Status Examination) and clinical interview, and were randomly allocated into the intervention and control groups. The intervention group (n=25) received a Mindfulness-Based Stress Reduction (MBSR) program in addition to the health education program in eight sessions, whereas the control group (n=25) received only the health education program. To measure the anxiety and depression score before and after study, the Hospital Anxiety and Depression Scale were used. Data were analyzed by SPSS version 11.5, using Analysis of Covariance (ANCOVA), t-test, Chi-square, Mann-Whitney U, and Fisher exact test.