Selectfluor‐promoted Synthesis of 2,4‐ and 2,6‐Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF

Abstract

Abstract An efficient one‐pot four‐component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4‐diarylsubstituted pyridines promoted by Selectfluor has been achieved. Symmetrical pyridines were obtained selectively when non‐methyl ketones were used as the starting materials. Two C−C and C−N bonds are formed during the oxidative cyclization process.