Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel

Abstract

Continuous administration of clopidogrel significantly improved tissue oxygenation, limited microvascular leakiness, and prevented airway ischemia. These data demonstrate that clopidogrel ameliorates microvascular injury during acute airway rejection, which is a known predisposing factor for the development of CLAD.