Pd(<scp>ii</scp>)-Catalyzed decarboxylative <i>meta</i>-C–H difluoromethylation

Abstract

A palladium(ii)-catalyzed decarboxylative meta-selective C-H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a reasonable migratory insertion is involved in this meta-C-H functionalization.