Cardioprotective Activity of Telmisartan, Metformin and its Combination against Doxorubicin Induced Myocardial Infarction in Rat Model

Abstract

Objective: The present study was designed to investigate the cardioprotective activity of telmisartan, metformin and its combination against doxorubicin induced myocardial infarction in rat by biochemical analysis. Methods: The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The study was conducted in albino wister rats (n=24) by using doxorubicin as negative control. the test drug, telmisartan and metformin was given alone and in combination for 15 days orally, on 14th & 15th day doxorubicin(15mg/kg) was injected intraperitoneally after the drug admistration except the normal control group. Results: The biochemical parameters, Troponin T shown to be negative for drug treated groups and positive for doxorubicin group (negative control). lactate dehydrogenase and CK-MB decreased for drug treated group then the negative control. Conclusion: These results suggest that the telmisartan and metformin treatment provides a significant cardioprotecive protective effect against acute-doxorubicin induced myocardial infarction in rats.