Recent Developments in the Synthesis of Nitrogen-Containing Heterocycles through C–H/N–H Bond Functionalizations and Oxidative Cyclization

Abstract

The synthesis and structure of nitrogen-containing heterocycles are fascinating because these compounds have a great richness of structural, physicochemical, and biological properties. Therefore, the development of improved ways for the synthesis of polyfunctional nitrogen-containing heterocycles continues to be a challenging goal. This account describes developments in the discovery of C–H/N–H bond functionalization and oxidative cyclization procedures for the synthesis of nitrogen-containing heterocycles (aziridines, indoles, indolizines, triazoles, imidazoles, oxazoles, thiazoles, quinoxalines, triazines, and pyridines) in our laboratories during the last 15 years. 1 Introduction 2 Synthesis of Aziridines 3 Synthesis of Indoles and Indolizines 4 Synthesis of Triazoles 5 Synthesis of Imidazoles 6 Synthesis of Oxazoles and Thiazoles 7 Synthesis of Quinoxalines, Triazines, and Pyridines 8 Conclusion and Outlook