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Divergent Oxidative Couplings between Indoles and 2,3-Dihydroxybenzoic Acid Derivatives for the Biomimetic Synthesis of Voacalgine A and Bipleiophylline
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2018
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BiosynthesisBioorganic ChemistryBiomimetic SynthesisBiochemistryBiosynthetic Precursor VoacalgineEngineeringNatural SciencesNatural Product BiosynthesisOrganic ChemistryNatural ProductsDivergent Oxidative CouplingsVoacalgine APharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
The present feature article details our endeavors towards the synthesis of the highly intricate bisindole alkaloid bipleiophylline and its biosynthetic precursor voacalgine A: from the development of a divergent oxidative coupling between indole and dihydroxybenzoic acids, to the exploration of the chemical space from natural products and culminating in the biomimetic assembly of voacalgine A and bipleiophylline.