Concepedia

Publication | Open Access

MuSK myasthenia gravis monoclonal antibodies

DOIFull Paper Access

86

Citations

25

References

2019

Year

Maartje G. Huijbers, Dana L.E. Vergoossen, Yvonne E. Fillié‐Grijpma, Inge E. van Es, Marvyn T. Koning, Linda M. Slot, Hendrik Veelken, Jaap J. Plomp, Silvère M. van der Maarel, Jan J.G.M. Verschuuren
Neurology Neuroimmunology & Neuroinflammation

Abstract

Patient-derived MuSK antibodies can act either as MuSK agonist or MuSK antagonist, depending on the number of MuSK binding sites. Functional monovalency, induced by Fab-arm exchange in patient serum, makes MuSK IgG4 antibodies pathogenic.

References

YearCitations

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