Vancomycin elution from a biphasic ceramic bone substitute

Abstract

This is the first long-term pharmacokinetic study that reports vancomycin release from a biphasic injectable ceramic bone substitute. The study shows initial high targeted local vancomycin levels, sustained and complete release at three weeks, and systemic concentrations well below toxic levels. The plain ceramic bone substitute has been proven to regenerate bone but should also be useful in preventing bone infection.<b>Cite this article</b>: M. Stravinskas, M. Nilsson, A. Vitkauskiene, S. Tarasevicius, L. Lidgren. Vancomycin elution from a biphasic ceramic bone substitute. <i>Bone Joint Res</i> 2019;8:49-54. DOI: 10.1302/2046-3758.82.BJR-2018-0174.R2.