Concepedia

Publication | Open Access

The MC<sub>4</sub> receptor agonist RO27‐3225 inhibits NLRP1‐dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage

DOIFull Paper Access

80

Citations

55

References

2019

Year

Shengpan Chen, Yuchun Zuo, Lei Huang, Prativa Sherchan, Jian Zhang, Zhengtao Yu, Jianhua Peng, Junyi Zhang, Lianhua Zhao, Desislava Doycheva,
British Journal of Pharmacology

Abstract

RO27-3225 suppressed NLRP1-dependent neuronal pyroptosis and improved neurological function, possibly mediated by activation of MC<sub>4</sub> receptor and inhibition of ASK1/JNK/p38 MAPK signalling pathways, after experimental ICH in mice. The MC<sub>4</sub> receptor may be a promising therapeutic target for the management of ICH.

References

YearCitations

Page 1