Inhibitory Effects of Berberine Hydrochloride on Trichophyton mentagrophytes and the Underlying Mechanisms

Abstract

Berberine hydrochloride could inhibit the growth of <i>T. mentagrophytes</i>. Berberine hydrochloride could also cure dermatosis induced by <i>T. mentagrophytes</i>. Down-regulation of 14α-demethylase exposed to various medicines was slightly different and might be one of the anti-resistance mechanisms of berberine hydrochloride in <i>T. mentagrophytes</i>. The present investigation provides considerable transcript sequence data that would help further assess the antifungal mechanisms against <i>T. mentagrophytes</i>, for antifungal medicine development.