New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities

Abstract

The <i>Chrysanthemum morifolium</i> flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (<b>1, 2</b>), a new flavanone glycoside (<b>3</b>), and six reported flavanones (<b>4</b>⁻<b>9</b>) were isolated and identified from the flowers of <i>C. morifolium</i>. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents <b>1</b>⁻<b>8</b> were evaluated for their neuroprotective activity, and compounds <b>3</b> and <b>4</b> displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.