Bioactive 3,8‐Epoxy Iridoids from <i>Valeriana jatamansi</i>

Abstract

Abstract Twelve 3,8‐epoxy iridoids, including four new compounds, jatamanins R–U ( 1 – 4 ), and eight known compounds ( 5 – 12 ), were obtained from the roots and rhizomes of Valeriana jatamansi . The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1 – 4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC‐18# (IC 50 =1.351 and 4.439 μg ml −1 , respectively) and GSC‐3# (IC 50 =10.88 and 6.348 μg ml −1 , respectively) glioma stem cells, while compound 12 was also slightly less potent against GSC‐12# (IC 50 =13.45 μg ml −1 ) glioma stem cell growth. In addition, compounds 9 and 12 displayed obvious inhibition of NO production (IC 50 =4.6 and 15.8 μ m , respectively).