Tumor mutational profile of triple negative breast cancer patients in Thailand revealed distinctive genetic alteration in chromatin remodeling gene

Abstract

This result supported that TNBC breast cancer patients from various ethnic background showed diverse genome alteration pattern. Although <i>TP53</i> is the most commonly mutated gene across all cohorts, Thai TNBC showed different gene mutation frequencies, especially in <i>KMT2C</i>. In particular, the cancer gene mutations are more prevalent in Thai TNBC patients. This result provides important insight on diverse underlying genetic and epigenetic mechanisms of TNBC that could translate to a new treatment strategy for patients with this disease.