The asymmetric construction of CF₃-containing spiro-thiazolone-pyrrolidine compounds<i>via</i>[3 + 2] cycloaddition

Abstract

The first organocatalytic method for the asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds has been developed. This is one of the very few methods to reach spiro-thiazolones, and afforded the products in excellent yields and stereoselectivities catalysed by only 1 mol% cinchona alkaloid-derived catalyst.