Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism

Abstract

Our data and rescue experiments support mutations in <i>SHANK3</i> as causal for GI transit and motility abnormalities. Reductions in serotonin-positive EECs and serotonin-filled ENS boutons suggest an endocrine/neural component to this dysmotility. This is the first study to date demonstrating DT dysmotility in a zebrafish single gene mutant model of ASD.