Upregulation of lncRNA NR_046683 Serves as a Prognostic Biomarker and Potential Drug Target for Multiple Myeloma

Abstract

Aim:To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma(MM). Methods:high-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients and controls. Results:It was found for the first time that lncRNA NR_046683is closely related to the prognosis of MM. It was also detected in tumor cell lines KM3, U266,especially in drug-resistant cell lines KM3/BTZ and MM1R. The NR_046683 expression differed significantly in patients of different MM subtypes and staging. Moreover, the overexpression of NR-046683is closely related to β2-microglobulin. We also found that the overexpression of NR-046683correlates to chromosomal aberrations, such as del(13q14), gain 1q21 and t(4;14). Conclusion: lncRNA NR_046683 can serve as a novel biomarker for potential drug target and prognostic prediction in MM.