Nickel-catalyzed oxidative C–H/N–H annulation of <i>N</i>-heteroaromatic compounds with alkynes

Abstract

The reaction of N-heteroaromatic compounds, such as 2-aryl-pyrrole, benzimidazole, imidazole, indole, and pyrazole derivatives, with alkynes in the presence of a catalytic amount of a nickel complex results in C–H/N–H oxidative annulation.