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Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti

Kathleen F. Walsh, Stalz Charles Vilbrun, Ariadne Souroutzidis, Sobieskye Delva, Guy Joissaint, L Mathurin, Oksana Ocheretina, Pierre Y. Crémieux, Jean W. Pape, Serena P. Koenig

Clinical Infectious Diseases · 2019 · 30 citations · 4 references

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Abstract

We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

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Marlanka A. Zuur, Jotam G. Pasipanodya, Dick van Soolingen et al. · Clinical Infectious Diseases · 2018 · 30 citations · Full text

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Burkhard Springer, Romana Calligaris-Maibach, Claudia Ritter et al. · Journal of Clinical Microbiology · 2008 · 21 citations · Full text

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