Depressive symptom‐associated <scp>IL</scp>‐1β and <scp>TNF</scp>‐α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma

Abstract

Asthma patients with depressive symptoms present worse asthma control, which is most likely explained by impaired BDR and neutrophilic airway inflammation. IL-1β and TNF-α, which are two key pro-inflammatory cytokines that mediate the correlation of depressive symptoms with impaired BDR and neutrophilic airway inflammation, may serve as targeted biomarkers in the neuropsychological phenotype of asthma; however, this result needs to be further validated.