Concepedia

Hypertrophic cardiomyopathy mutations in <i>MYBPC3</i> dysregulate myosin

Christopher N. Toepfer, Hiroko Wakimoto, Amanda C. Garfinkel, Barbara McDonough, Dan Liao, Jianming Jiang, Angela C. Tai, Joshua Gorham, Ida G. Lunde, Mingyue Lun,

Science Translational Medicine · 2019 · 214 citations · 45 references

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Concepts

Abstract

Mutations in MYBPC3 disrupt myosin states of relaxation, and manipulating myosin therapeutically abates the effects of MYBPC3 mutations.

References

45

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