Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1<i>H</i>)-ones with amidates under microwave irradiation

Abstract

A novel and convenient protocol for the construction of 3-amidated quinoxalin-2(1<italic>H</italic>)-ones was developed <italic>via</italic> copper-catalyzed direct oxidative amidation of quinoxalin-2(1<italic>H</italic>)-ones with amidates using K₂S₂O₈ as an oxidant, and under microwave irradiation.