Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling

A trust region method based on interior point techniques for nonlinear programming

Richard H. Byrd, Jean Charles Gilbert, Jorge Nocedal · Mathematical Programming · 2000 · 1.6K citations

Natural Sciences, Computer Science, Optimization +6

Steric mass‐action ion exchange: Displacement profiles and induced salt gradients

Clayton A. Brooks, Steven M. Cramer · AIChE Journal · 1992 · 557 citations

Pharmacy, Biochemistry, Chromatographic Analysis +16

High-throughput isotherm determination and thermodynamic modeling of protein adsorption on mixed mode adsorbents

Beckley K. Nfor, Marc Noverraz, Sreekanth Chilamkurthi et al. · Journal of Chromatography A · 2010 · 170 citations

Natural Sciences, Materials Science, Computational Chemistry +14

Protein Mass Transfer Kinetics in Ion Exchange Media: Measurements and Interpretations

Giorgio Carta, Antonio Ubiera, Timothy M. Pabst · Chemical Engineering & Technology · 2005 · 168 citations

Engineering, Biochemistry, Chemistry +17

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

Matthias Wiendahl, P. Schulze Wierling, Jacob Nielsen et al. · Chemical Engineering & Technology · 2008 · 126 citations

Pharmacy, Biochemistry, Chemistry +16