Tin‐Mediated One‐Pot Preparation of β‐Trifluoromethyl‐β<i>‐</i> acylhydrazonyl Carbonyl Compounds

Abstract

Abstract A concise and efficient protocol for the preparation of β‐trifluoromethyl‐β‐acylhydrazonyl carbonyl compounds was developed from multicomponent one‐pot reactions of trifluoroacetaldehyde methyl hemiacetal, acylhydrazines and 2‐bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.