Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities

Abstract

Two new phenolic glucosides, pipercroside A and B (<b>1</b> and <b>2</b>), along with 10 known compounds were isolated from the leaves of <i>Piper crocatum</i> Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (<b>5</b>) showed inhibitory activity with an IC₅₀ value of 58.5 µM.