Overexpression of Stimulatory G Protein Alpha-subunit Is a Hallmark of Most Human Somatotrophic Pituitary Tumours and Is Associated with Resistance to GH-releasing Hormone

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

Andrew D. Howard, Scott D. Feighner, Doris Cully et al. · Science · 1996 · 2.1K citations

Human Growth, Growth Hormone Secretagogues, Pituitary Gland +17

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

Claudia A. Landis, Susan B. Masters, Anna Spada et al. · Nature · 1989 · 1.4K citations

Adenylyl Cyclase, Signal Transduction, Molecular Physiology +11

Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas

Lucia Vallar, A. Spada, G. Giannattasio · Nature · 1987 · 518 citations

Pituitary Gland, Growth Hormone, Endocrine Mechanism +9

Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene

Frank H. Burton, Karl W. Hasel, Floyd E. Bloom et al. · Nature · 1991 · 191 citations

Knockout Mouse, Pituitary Gland, Autoimmune Disease +9

Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.

John R. Hadcock, Manuel Ros, David C. Watkins et al. · Journal of Biological Chemistry · 1990 · 142 citations · Full text