A new antibacterial dibenzofuran-type phloroglucinol from <i>myrtus communis</i> linn

Abstract

Our continuation on the bio-assay guided isolation from <i>Myrtus communis</i> Linn. led to the discovery of a new dibezofuran type phloroglucinol 1,1'-(1,3,7,9-tetrahydroxydibenzo[b,d]furan-2,8-diyl)bis(ethan-1-one) <b>1</b>. The structure was established through detailed spectroscopic studies including one and two dimensional NMR spectroscopy and electrospray ionization high resolution mass spectrometer (ESI-HRMS). The crude acetone extract from <i>M. communis</i> (AMA), dichloromethane fraction (DCM), and the isolated pure compound <b>1</b> were tested against pathogenic bacteria. Compound <b>1</b> displayed higher antibacterial activity against the Gram-positive and Gram-negative <i>Staphlocococus aureus</i> and <i>Escherichia coli</i> respectively as compared to the crude extract and fractions.