<i>Aspergillus</i>species collected from environmental air samples in Portugal—molecular identification, antifungal susceptibility and sequencing of<i>cyp51A</i>gene on<i>A. fumigatus sensu stricto</i>itraconazole resistant

Abstract

This study is the first assessment of molecular resistance mechanisms in A. fumigatus sensu stricto environmental isolates, in Portugal. Since TR34/L98H and TR46/Y121F/T289A cyp51A mutations were already reported in the clinical setting in Portugal (Monteiro et al. J Glob Antimicron Resist 13: 190-191, 2018; Pinto et al. Front Microbiol 9: 1656, 2018), and have been linked to environmental route, it is utmost importance to perform surveillance network for azole-resistant A. fumigatus.