Robust Single-Shot T₂ Mapping via Multiple Overlapping-Echo Acquisition and Deep Neural Network

Abstract

Quantitative magnetic resonance imaging (MRI) is of great value to both clinical diagnosis and scientific research. However, most MRI experiments remain qualitative, especially dynamic MRI, because repeated sampling with variable weighting parameter makes quantitative imaging time-consuming and sensitive to motion artifacts. A single-shot quantitative T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> mapping method based on multiple overlapping-echo acquisition (dubbed MOLED-4) was proposed to obtain reliable T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> mapping in milliseconds. Different from traditional MRI acceleration methods, such as compressed sensing and parallel imaging, MOLED-4 accelerates quantitative T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> mapping via synchronized multisampling and then deep learning to map the complex nonlinear relationship that is difficult to solve by traditional optimization-based methods. The results of simulation, phantom, and in vivo human brain experiments show the great performance of the proposed method. The principle of MOLED-4 may be extended to other ultrafast quantitative parameter mappings and potentially lead to new dynamic MRI with high efficiency to catch quantitative variation of tissue properties.