Formulation and Evaluation of Antidiabetic and Antihyperlipidemic Activities of Polyherbal Formulation in Streptozotocin induced diabetic rat

Abstract

Gymnema sylvestre, Trigonella foenum and Phyllanthus emblica are used for the management of diabetes. The mixing of these plant parts in different ratio may produce synergistic antidiabetic action. Hence the aim of the present study was to formulate polyherbal formulations containing various proportions of Gymnema sylvestre (Leaves), Trigonella foenum (Seeds) and Phyllanthus emblica (Fruits) to investigate their antidiabetic and antihyperlipidemic activity in Streptozotocin induced diabetic rat. The physicochemical estimations namely total ash value, acid insoluble ash value, water soluble ash value, loss on drying, alcohol soluble extractive values and water soluble extractive value for plants parts were performed. The decoction of four different polyherbal formulations (HF1 to HF4) were prepared and antidiabetic activity was investigated in Streptozotocin induced diabetic rat. The physicochemical value of plant materials were under limits and acceptable. The administration of polyherbal formulation (HF1 to HF4) significantly decreased the blood glucose levels compared to control diabetic rats. The polyherbal formulation significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the high density lipoprotein (HDL) indicates the antihyperlipidemic activity. The findings demonstrated the antidiabetic and antihyperlipidemic activity of polyherbal formulations, and HF2 produce higher protective effect from diabetes.