Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways

Abstract

Our study suggests a key role for oxLDL and downstream CD36/TLR4/TRIF in regulating DPP4 expression. Increased DPP4 in response to oxidized lipids may represent an integrated mechanism linking post-prandial glucose metabolism to lipoprotein abnormality-potentiated atherosclerosis.