An Effective [Fe^III(TF₄DMAP)Cl] Catalyst for C–H Bond Amination with Aryl and Alkyl Azides

Abstract

[Fe^III(TF₄DMAP)Cl] can efficiently catalyze intermolecular sp³ C-H amination using aryl azides and intramolecular sp³ C-H amination of alkyl azides in moderate-to-high product yields. At catalyst loading down to 1 mol %, the reactions display high chemo- and regioselectivity with broad substrate scope and are effective for late-stage functionalization of complex natural/bioactive molecules.