Concepedia

Publication | Open Access

Cardiac sodium-dependent glucose cotransporter 1 is a novel mediator of ischaemia/reperfusion injury

DOIFull Paper Access

80

Citations

39

References

2019

Year

Li Zhao, Vineet Agrawal, Mohun Ramratnam, Ravi Sharma, Stephen D’Auria, Abigail Sincoular, Margurite Jakubiak, Meredith L Music, William Kutschke, Xueyin N. Huang,
Cardiovascular Research

Abstract

During ischaemia, AMPK up-regulates SGLT1 through ERK, and SGLT1 interacts with EGFR, which in turn increases PKC and Nox2 activity and oxidative stress. SGLT1 may represent a novel therapeutic target for mitigating I/R injury.

References

YearCitations

Page 1