Grape Seed Proanthocyanidins Protect N2a Cells against Ischemic Injury via Endoplasmic Reticulum Stress and Mitochondrial-associated Pathways - Concepedia

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Grape Seed Proanthocyanidins Protect N2a Cells against Ischemic Injury via Endoplasmic Reticulum Stress and Mitochondrial-associated Pathways

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2019

Year

Kun Fu, Liqiang Chen, Lifeng Miao, Yan Guo, Wei Zhang, Yun’an Bai

CNS & Neurological Disorders - Drug Targets

Abstract

Our findings suggest that GSP can protect N2a cells from OGD/R insult. The mechanism of anti-apoptotic effects of GSP may involve attenuating ER stress and mitochondrial dysfunction.