MMWR Morbidity and Mortality Weekly Report · 2019 · 56 citations · 9 references
MedicineInfectious DiseasesSurgeryHepatologyKidney TransplantationTransplant SurgeryDeceased Donor CareDeceased Donor TransplantationDonor ScreeningDonor SelectionLiver TransplantationViral HepatitisDeceased Donor AssessmentDonor Risk ReductionDrug Overdose MortalityHepatitis C Virus TransmissionHuman Immunodeficiency Virus TransmissionInfection Transmission RiskInfectious Risk AssessmentTransplantation
CDC analyzed deceased donor data for the period 2010-2017 reported to the Organ Procurement and Transplantation Network for IRDs and standard risk donors (SRDs) (i.e., donors who do not meet any of the criteria for increased risk designation). During this period, the proportion of IRDs increased approximately 200%, from 8.9% to 26.3%; the percentage with drug intoxication reported as the mechanism of death also increased approximately 200%, from 4.3% to 13.4%; and the proportion of these donors with reported injection drug use (IDU) increased approximately 500%, from 1.3% to 8.0%. Compared with SRDs, IRDs were significantly more likely to have positive HBV and HCV screening results. These findings demonstrate the continuing need for identifying viral bloodborne pathogen infection risk factors among deceased donors to reduce the risk for transmission, monitor posttransplant infection in recipients, and offer treatment if infection occurs.
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