Concepedia

Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain

Andrea Poch, Felipe Villanelo, Soledad Henríquez, Paulina Kohen, Alex Muñoz, Jerome F. Strauss, Luigi Devoto

Steroids · 2019 · 13 citations · 47 references

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47

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

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<i>PRODRG</i>: a tool for high-throughput crystallography of protein–ligand complexes

Alexander W. Schüttelkopf, Daan M. F. van Aalten · Acta Crystallographica Section D Biological Crystallography · 2004 · 4.8K citations · Full text

, , +16

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

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A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

Richard K. Bruick, Steven L. McKnight · Science · 2001 · 2.5K citations

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Hui-Qiao Tian, Steven L. McKnight, David W. Russell · Genes & Development · 1997 · 1.3K citations · Full text

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