Publication | Closed Access
Annulation of 1-(2-Aminoaryl)pyrroles, Ethers with Elemental Sulfur To Give 1,3,6-Benzothiadiazepine Derivatives through Double C–S Bond Formation and C–O Cleavage of Ethers
23
Citations
80
References
2019
Year
Chemical EngineeringDerivativesEngineering1,3,6-Benzothiadiazepine DerivativesHeterocyclicOrganic ChemistryTransition-metal-free ConditionsCatalysisElemental SulfurChemistryN-heterocycle-fused 1,3,6-BenzothiadiazepinesHeterocycle ChemistryPharmacologyDerivative (Chemistry)Synthetic ChemistryC–o Cleavage
An efficient three-component reaction of 1-(2-aminoaryl)pyrroles, ethers, and elemental sulfur for constructing N-heterocycle-fused 1,3,6-benzothiadiazepines under transition-metal-free conditions has been developed. Ethers act as both reactants and solvent in this reaction. The method proceeds efficiently over a broad range of substrates with good functional group tolerance.
| Year | Citations | |
|---|---|---|
Page 1
Page 1