Concepedia

Asymmetric Alkenylation of Enones and Imines Enabled by A Highly Efficient Aryl to Vinyl 1,4‐Rhodium Migration

Shu‐Sheng Zhang, Tianjiao Hu, Mengyao Li, Yi‐Kang Song, Xiaodi Yang, Chen‐Guo Feng, Guo‐Qiang Lin

Angewandte Chemie International Edition · 2019 · 64 citations · 62 references

DOI

Concepts

Abstract

The asymmetric rhodium-catalyzed alkenylation of enones and imines with arylboronic acids has been developed. A highly controllable aryl to vinyl 1,4-rhodium migration is the key step. Stereodefined vinyl moieties were installed in excellent enantioselectivies for most examined examples. DFT calculations reveal that the driving force of this rhodium migration is a kinetically favored process.

References

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