A responsive porous hydrogel particle-based delivery system for oncotherapy

Abstract

Liver cancer is one of the malignant cancers that seriously threatens human health. Although some common treatments including chemotherapy have been applied in oncotherapy, there are often serious shortcomings such as frequent and uncontrollable drug infusion. To overcome these limitations, here, we introduced responsive porous hydrogel microparticles loaded with 5-fluorouracil and metformin for oncotherapy. Because of the interconnected porous structures, various forms of active molecules could be loaded into the particles. In addition, the relatively higher temperature of the tumor site and the temperature-responsive shape transition of pNIPAM hydrogel enabled controllable drug release. The porous pNIPAM particles not only exhibited large loading efficiency and sustained release for the 5-fluorouracil and metformin co-delivery, but also protected drugs from being resolved. Thus, it can be anticipated that the porous microparticles will have great potential in oncotherapy.