Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

Abstract

Our data are consistent with a model in which TXNRD1 inhibition augments hyperoxia-induced GSH-dependent antioxidant responses in neonatal mice. Discrepancies between <i>in vivo</i> and <i>in vitro</i> results highlight the need for methodologies that permit accurate assessments of the GSH system at the single-cell level.