Concepedia

Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody–Negative Eosinophilic Granulomatosis with Polyangiitis

Manali Mukherjee, Sruthi Thomas, Katherine Radford, Anna Dvorkin‐Gheva, Svetlana Davydchenko, Melanie Kjarsgaard, Sarah Svenningsen, Sarah Almas, Lindsey C. Felix, Jennifer Stearns,

American Journal of Respiratory and Critical Care Medicine · 2018 · 56 citations · 25 references

DOI

Abstract

We report a novel finding of ANCA reactivity in the sputa of patients with eGPA in whom disease severity is driven by respiratory complications. Investigating localized autoimmunity may lead to the discovery of novel pathomechanisms, therapeutic targets, and optimal biomarkers for diagnosing and managing eGPA.

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