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Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors

Kelly Smart, Sylvia M. L. Cox, Stephanie G. Scala, Maria Tippler, Natalia Jaworska, Michel Boivin, Jean R. Séguin, Chawki Benkelfat, Marco Leyton

European Journal of Nuclear Medicine and Molecular Imaging · 2019 · 74 citations · 17 references

DOIFull text

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Abstract

Binding availability of mGlu5 receptors as measured by PET [<sup>11</sup>C]ABP688 is higher in healthy men than women. This likely represents a source of variability in [<sup>11</sup>C]ABP688 studies and could have relevance for sex differences in cognitive-behavioral functions and neuropsychiatric disorders.

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