Concepedia

Highly Regioselective, Acid-Catalyzed, Three-Component Cascade Reaction for the Synthesis of 2-aminopyridine-Decorated Imidazo[1,2-<i>a</i>]pyridine

Qiuxing He, Yao-Feng Liang, Chang Xu, Xiaokun Yao, Hua Cao, Hua–Gang Yao

ACS Combinatorial Science · 2019 · 14 citations · 31 references

DOI

Concepts

Abstract

A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction of imidazo[1,2- a]pyridine has been developed. This strategy provides a broad range of substrates and represents an efficient approach to give various 2-aminopyridine-decorated imidazo[1,2- a]pyridine in good yields.

References

31

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Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABA<sub>A</sub>) Receptor Are Different

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