Biological and molecular effects of bromodomain and extra‐terminal (<scp>BET</scp>) inhibitors <scp>JQ</scp>1, <scp>IBET</scp>‐151, and <scp>IBET</scp>‐762 in <scp>OSCC</scp> cells

Abstract

BET inhibitors induce both OSCC cell death and reduction of tumor aggressiveness. Molecular mechanisms of BET inhibition involve among others, MCM5 downregulation. Importantly, this study demonstrates for the first time the anti-tumoral effect of IBET-151 and IBET-762 in oral cancer.