Comparison of obstetric outcomes of pregnancies after donor-oocyte In vitro fertilization and self-oocyte In vitro fertilization: A retrospective cohort study

Abstract

<br><b>Aims:</b>The aim of this study is to evaluate and compare multiple obstetric and perinatal outcomes between donor-oocyte <i>in vitro</i> fertilization (IVF) and self-oocyte IVF group. <b>Settings and Design:</b> This study was done in a tertiary care center with ART unit. This was a retrospective comparative cohort study. <b>Materials and Methods:</b> The present study comprised all women between 20 and 45 years who conceived from oocyte donation (<i>n</i> = 78) between December 1, 2010, and December 31, 2016, and compared with all women who underwent self-oocyte IVF (<i>n</i> = 112). The process involved controlled ovarian stimulation and retrieval of the donor oocytes, preparation of recipient endometrium, and pregnancy management. Obstetric and perinatal outcomes were compared. <b>Statistical Analysis Used:</b> Chi-square test was used for categorical variables. Analysis for confounding variables was performed using multivariable linear and logistic regression analysis. <b>Results:</b> Baseline characteristics between the two groups were comparable. Miscarriage, first-trimester bleeding, pregnancy-induced hypertension (PIH), and gestational diabetes mellitus were significantly higher in donor-oocyte IVF group compared to self-oocyte cycles (<i>P</i> = 0.001). Using multiple logistic regression analysis, age class adjusted PIH incidence was significantly higher in donor-oocyte group as compared to self-oocyte group (<i>P</i> = 0.010). There was no significant variation in perinatal outcomes between the donor- and self-oocyte IVF cycles (<i>P</i> > 0.05). <b>Conclusion:</b> Oocyte donation should be treated as an independent risk factor for PIH.<br>